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翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク Fatty acid metabolism regulator protein FadR ： ウィキペディア英語版 Fatty acid metabolism regulator protein FadR In molecular biology, the fatty acid metabolism regulator protein FadR, is a bacterial transcription factor. Bacteria regulate membrane fluidity by manipulating the relative levels of saturated and unsaturated fatty acids within the phospholipids of their membrane bilayers. In ''Escherichia coli'', the transcription factor, FadR, functions as a switch that co-ordinately regulates the machinery required for fatty acid beta-oxidation and the expression of a key enzyme in fatty acid biosynthesis. This single [repressor controls the transcription of the whole ''fad'' regulon. Binding of fadR is specifically inhibited by long chain fatty acyl-CoA compounds. The crystal structure of FadR reveals a two domain dimeric molecule where the N-terminal winged-helix domain binds DNA, and the C-terminal domain binds acyl-CoA.〔 The binding of acyl-CoA to the C-terminal domain results in a conformational change that affects the DNA binding affinity of the N-terminal domain. FadR is a member of the GntR family of bacterial transcription regulators. The DNA-binding domain is well conserved for this family, whereas the C-terminal effector-binding domain is more variable, and is consequently used to define the GntR subfamilies. The FadR group is the largest subgroup, and is characterised by an all-helical C-terminal domain composed of 6 to 7 alpha helices.〔 ==References== 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Fatty acid metabolism regulator protein FadR」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.